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Funded Research

Characterizing upstream environmental, social, and economic determinants of health and their association with cancer-related health outcomes

Substantial prior research supports an inverse association between area-level poverty and adverse health outcomes, including cancer incidence and mortality. Persistent poverty areas, or those where at least 20% of the population has reported incomes below the federal poverty level (FPL) for thirty or more years, represent an important sub-category of high-poverty areas, where residents may be exposed to the adverse effects of social and economic deprivation for decades, and where such long-term exposure may perpetuate intergenerational poverty and its adverse impacts on health. One way to frame associations between environmental factors and individual cancer risk and outcomes is through the Integrated Conceptual Framework for Understanding and Addressing Social Determinants to Advance Cancer Health Equity. This framework specifies upstream levels, including social inequities & social justice; institutional environments; and economic, physical, social, and service living environments that contribute to disparities in individual risk factors and cancer outcomes. This proposal seeks to characterize the upstream conditions identified by this framework in the persistent, current, and low poverty census tracts in the Karmanos Cancer Institute (KCI) catchment area and throughout Michigan by 1) developing a data resource of variables characterizing the upstream factors (social inequities & social justice; institutional environments; and economic, physical, social, and service living environments) in the framework in the KCI catchment area and across Michigan; 2) characterizing the upstream factors of persistent, current, and low poverty census tracts using those data; and 3) evaluating associations between individual components of the framework and cancer prevention, incidence, mortality, and survivorship outcomes.

Funding:

Wayne State University

Funding Period:

07/01/2024 to 06/30/2025