Ch. 1. Ethical considerations — Ch. 2. Assessment measures and clinical scales — Ch. 3. Ethics, outcome variables and clinical scales: the clinician's point of view — Ch. 4. The Cochrane collaboration reviews in neurology — Ch. 5. Drug development stages — Ch. 6. Drug regulatory requirements in the United Kingdom and Europe — Ch. 7. Drug regulatory requirements in the United States — Ch. 8. Quality control and data monitoring: a guide to good clinical practice — Ch. 9. Statistical issues in clinical trials in neurology — Ch. 10. Analysis of results: statistical principles — Ch. 11. Survival analysis — Ch. 12. The intention-to-treat principle for clinical trials — Ch. 13. Statistical analysis of repeated-measures data with drop-outs — Ch. 14. The role of meta-analyses in clinical research: uses and limitations — Ch. 15. Outcome variables in dementia trials: conceptual and practical issues — Ch. 16. Dementia: trial design and experience with large multicentre trials — Ch. 17. Cerebrovascular disease: basic designs, sample sizes and pitfalls — Ch. 18. Clinical trials in stroke prevention in North America — Ch. 19. Cerebrovascular disease: experience within large multicentre trials — Ch. 20. Epilepsy: ethics, outcome variables and clinical scales — Ch. 21. Epilepsy: basic designs, sample sizes and experience with large multicentre trials — Ch. 22. Headache: ethics, outcome variables and clinical studies — Ch. 23. Headache: basic trials designs, sample sizes and pitfalls — Ch. 24. Headache: experience with large multicenter trials in the treatment of migraine attacks — Ch. 25. Parkinson's disease: outcome variables and clinical scales — Ch. 26. Parkinson's disease: a review of drug trials — Ch. 27. Parkinson's disease: experience with large multicentre trials — Ch. 28. Tremor: clinical measurement of impairment, disability and handicap — Ch. 29. Tremor: natural behaviour, trial design and physiological outcome measures — Ch. 30. Multiple sclerosis: ethics, outcome variables and clinical scales — Ch. 31. Multiple sclerosis: study design, sample sizes and pitfalls — Ch. 32. Multiple sclerosis: experience with large clinical trials — Ch. 33. Motor neurone disease: ethics, outcome variables and clinical scales — Ch. 34. Motor neurone disease: basic designs, sample sizes and pitfalls — Ch. 35. Motor neurone disease: experience with large multicentre trials — Ch. 36. Peripheral neuropathies: controlled clinical trials — Ch. 37. Peripheral neuropathies: experience with large multicentre trials — Ch. 38. Disorders of the neuromuscular junction: outcome measures and clinical scales — Ch. 39. Myasthenia gravis: basic designs, sample sizes and pitfalls — Ch. 40. Myopathies: ethics, outcome variables and clinical scales — Ch. 41. Myopathies: basic designs, sample sizes and pitfalls.