This project will include investigators at five Michigan institutions and will focus on three primary aims:
AIM 1: To investigate the effects of persistent organic pollutants (POPs) and heavy metals, assessed across two generations, on ECHO outcomes.
AIM 2: To assess the effect of maternal nutritional/weight status in pregnancy on ECHO outcomes.
AIM 3: To assess effects of pregnancy infection and inflammation (assessed in maternal blood, placenta and newborn blood spots) on ECHO outcomes.