David Marc Fresco
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BIO
David M. Fresco is Professor of Psychiatry and Faculty Affiliate at the Institute for Social Research (ISR). His program of research adopts an affective neuroscience perspective to conduct basic, translational, and treatment studies of anxiety and mood disorders, particularly distress disorders (e.g., major depressive disorder, generalized anxiety disorder, and post-traumatic stress disorder) incorporating methodologies including functional neuroimaging (fMRI & EEG), peripheral psychophysiology, and serum markers (e.g., inflammation, neurodegeneration).
Another facet of Dr. Fresco’s research has focused on the development of treatments informed by affective and contemplative neuroscience findings that incorporate mindfulness meditation and other practices derived from Buddhist mental training exercises.
Increasingly, with collaborators at ISR, Dr. Fresco has initiated clinical trials for treatment optimization and implementation utilizing adaptive intervention methodology (e.g., sequential multiple assignment randomized trials [SMART] & just-in-time adaptive interventions [JITAIs])
Much of his current and recent NIH-funded research has focused on examining neurobehavioral mechanisms and efficacy of mindfulness-enriched treatments for chronic illnesses, and the role of emotion regulation strategies in everyday life to reduce distress.
- Szkutak, Abigail, Lee, Hana H., Quintero, Jean M., Aldao, Amelia, David Marc Fresco, Mennin, Douglas S.. 2026. Changes in phasic heart rate variability predict clinical outcomes following Emotion Regulation Therapy for generalized anxiety disorder and comorbid depression. Behavior Therapy
- Sgherza, Tanika R., Becerra, Rodrigo, Bylsma, Lauren M., David Marc Fresco, Naragon-Gainey, Kristin. 2026. Investigating functional impairment as a mediator of the association between internalising symptoms and low wellbeing. Journal of Affective Disorders :121517.
- Sgherza, Tanika R., Becerra, Rodrigo, Bylsma, Lauren M., David Marc Fresco, Naragon-Gainey, Kristin. 2026. The protective effect of decentering on the links between internalising symptoms, functional impairment and wellbeing. Behavior Therapy
- Phillip Spaeth, Megan Renna, Mia Skytte O'Toole, Douglas S. Mennin, David Marc Fresco. 2025. Emotion Regulation Therapy III: Foundations and Frontiers in Investigating Efficacy and Mechanism. The Palgrave Handbook of Third-Wave Psychotherapies :293-312.
- Amy F. Sato, Caroline E. West, David Marc Fresco, Shirley M. Moore, Elissa elalian. 2024. Development of a mindfulness-based pediatric weight management intervention for adolescents: findings from a pilot trial adapted for telehealth delivery. Children's Health Care 55(1):2-25.
- Hu, Xin, Sgherza, Tanika R., Nothrup, Jessie B., David Marc Fresco, Naragon-Gainey, Kristin, Bylsma, Lauren M.. 2024. From lab to life: Evaluating the reliability and validity of psychophysiological data from wearable devices in laboratory and ambulatory settings. Behavior Research Methods 56:1-20.
- Liudmila Gamaiunova, Rebecca Shankland, Michael Moore, Eric Mayor, Grégory Dessart, Ilios Kotsou, David Marc Fresco. 2024. Measuring Decentering - Development and Validation of the French Version of the Experiences Questionnaire (EQ-F). Psychological Test Adaptation and Development 5:229–241.
- Lilia T. Popova, Rebhi O. Abuzaitoun, David Marc Fresco, Maria Fernanda Abalem, Chris A. Andrews, David C. Musch, Josh Ehrlich, K. Thiran Jayasundera. 2023. Positive feedback loop between vision-related anxiety and self-reported visual difficulty. Ophthalmic Genetics 44(4):327-333.
- Kalmbach, David A., Cheng, Philip, Reffi, Anthony N., Ong, Jason C., Swanson, Leslie M., David Marc Fresco, Walch, Olivia, Seymour, Grace M., Fellman-Couture, Cynthia, Bayoneto, Alec D., Roth, Thomas, Drake, Christopher L.. 2023. Perinatal Understanding of Mindful Awareness for Sleep (PUMAS): A single-arm proof-of-concept clinical trial of a mindfulness-based intervention for DSM-5 insomnia disorder during pregnancy. Sleep Medicine 108:79-89.
- Renna, Megan E., Spaeth, Phillip E., Quintero, Jean M., O'Toole, Mia S., Sandman, Christina F., David Marc Fresco, Mennin, Douglas S.. 2023. A randomized controlled trial comparing two doses of emotion regulation therapy: Preliminary evidence that gains in attentional and metacognitive regulation reduce worry, rumination, and distress. Behaviour Research and Therapy 170:104420.