Wei Zhao
- Email Wei Zhao
- (734)647-1771
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BIO
Wei Zhao is a Research Assistant Professor at the Survey Research Center in the Institute for Social Research at the University of Michigan (UM) and is affiliated with the Center for Social Epidemiology and Population Health (CSEPH), the Michigan Center on the Demography of Aging (MiCDA), the Eisenberg Family Depression Center, and the UM Precision Health. Dr. Zhao is an interdisciplinary researcher with training in genetic epidemiology, statistics, psychology, and neuroscience. Her research aims to understand the genetic architecture of complex human diseases and traits. She applies cutting-edge high-dimensional statistical models and methods to investigate the relationship between multi-omics (genomics, epigenomics, transcriptomics), social/environmental factors, and complex traits in multi-ancestry populations. She has studied a variety of health outcomes and behaviors with a recent focus on cognition, dementia, and mental health-related traits. Dr. Zhao has been a key player in the genomic data cleaning and analytical efforts of multiple large-scale studies, including the Health and Retirement Study (HRS), The Longitudinal Study of Aging in Indian -Diagnostic Assessment of Dementia (LASI-DAD), the Genetic Epidemiology Network of Arteriopathy Study (GENOA), and the Study of Women’s health Across the Nation (SWAN). She currently leads the genomic data collection and dissemination efforts in the Panel Study of Income Dynamics (PSID).
- Meng Lai, ..., Wei Zhao, Jessica Danielle Faul, Jennifer Ann Smith, et al.. 2025. Epigenome-wide association study of nuclear DNA methylation in relation to mitochondrial heteroplasmy. Nature Communications 16(1):10962.
- Jennifer Ann Smith, Hasan Abu-Amara, Wei Zhao, Zheng Li, Yuk Yee Leung, Gerald D. Schellenberg, Li-San Wang, Priya Moorjani, Eileen M. Crimmins, Bharat Thyagarajan, Masroor Anwar, Peifeng Hu, Sharmistha Dey, Aparajit Ballav Dey, Xiang Zhou, Kumarasamy Thangaraj, Jinkook Lee, Sharon L R Kardia. 2025. Gene‐centric analysis using functional annotation identifies genetic associations with blood‐based biomarkers of Alzheimer's disease in older adults from India. Alzheimer's & Dementia 21:e099411.
- Wei Zhao, Zheng Li, Jennifer Ann Smith, Hasan Abu-Amara, Yuk Yee Leung, Gerald D. Schellenberg, Li-San Wang, Priya Moorjani, Eileen M. Crimmins, Bharat Thyagarajan, Masroor Anwar, Peifeng Hu, Sharmistha Dey, Xiang Zhou, Kumarasamy Thangaraj, Aparajit Ballav Dey, Jinkook Lee, Sharon L R Kardia. 2025. Genetic variants in MAPT are associated with Alzheimer's disease blood biomarkers in South Asians from the Longitudinal Aging Study in India‐Diagnostic Assessment of Dementia. Alzheimer's & Dementia 21:e100340.
- Raymond Noordam, ..., Wei Zhao, Jennifer Ann Smith, et al.. 2025. Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants. Atherosclerosis 412
- Lundin, Jessica I., ..., Farah Ammous, Jennifer Ann Smith, Wei Zhao, et al.. 2025. Epigenetic mechanisms underlying variation of IL-6, a well-established inflammation biomarker and risk factor for cardiovascular disease. Atherosclerosis
- Opsasnick, Lauren A., Wei Zhao, Schmitz, Lauren L., Ratliff, Scott M., Jessica Danielle Faul, Zhou, Xiang, Belinda Needham, Jennifer Ann Smith. 2025. Depressive symptoms partially mediate the relationship between psychosocial factors and epigenetic age acceleration in a multi-racial/ethnic sample of older adults. Brain, Behavior, & Immunity - Health 45:100994.
- Margaret Sunitha Selvaraj, ..., Wei Zhao, Jennifer Ann Smith, et al.. 2025. Whole genome sequence analysis of low-density lipoprotein cholesterol across 246K individuals. Genome Biology 26(1):273.
- Konstantinos Hatzikotoulas, ..., Wei Zhao, Jessica Danielle Faul, Jennifer Ann Smith, David R Weir, et al.. 2025. Translational genomics of osteoarthritis in 1,962,069 individuals. Nature
- Roselli, Carolina, ..., Jessica Danielle Faul, Wei Zhao, Jennifer Ann Smith, Et al.. 2025. Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases. Nature Genetics 57:539-547.
- Lisha Lin, Wei Zhao, Zheng Li, Scott M. Ratliff, Yi Zhe Wang, Colter Mitchell, Jessica Danielle Faul, Sharon L. R. Kardia, Kira S Birditt, Jennifer Ann Smith. 2025. Poly-epigenetic scores for cardiometabolic risk factors interact with demographic factors and health behaviors in older US Adults. Epigenetics 20(1):2469205.